Humboldt State University ® Department of Chemistry

Richard A. Paselk

Biochemical Toxicology

Lecture Notes, Spring 2010

These are the notes I am using to present my lectures. They are here for the convenience of my students. They are unedited and thus liable to error. The expansions and corrections I put in during my lectures are not included. Use them at your own risk! If you find errors in my notes, please inform me ASAP via e-mail: rap1 @ axe.humboldt.edu

• Lecture 1; January 19: Introduction, What is Toxicology?
• Lecture 2; January 21: Biology Review; Cell Structure. Lecture 2 Slide
• Lecture 3; January 26: Membranes and Membrane Structure.Introduction to Proteins Lecture 3 Slide
• Lecture 4; January 28: Proteins. Lecture 4 Slide
• Lecture 5; February 2: Enzymes and Metabolism; Dose-Response Relationships.
• Lecture 6; February 4: Dose-Response Curves - Quantitation of Dose-Response.
• Lecture 7; February 12: Quantitation of Dose-Response cont.
• Lecture 8; February 16: Absorption and Distribution: Factors Affecting Transport.
• Lecture 9; February 18: Absorption and Distribution, cont.: Effects of Ionization; Protein Binding; Introduction to Toxicokinetics. Lecture 9 Slide
• Lecture 10; February 23: Toxicokinetics, cont.
• Lecture 11; February 25: Toxicokinetics, cont.; Excretion; Toxicant Metabolism - Phase One Reactions. Lecture 11 Slide
• Lecture 12; February 28: Phase One Monooxygenases - Example Reactions; P₄₅₀ mechanism. Lecture 12 Slide
• Lecture 13; March 9: Non- P₄₅₀ Oxidations; Reduction Reactions; Hydrolysis Reactions; Phase Two Reactions. Lecture 13 Slide
• Lecture 14; March 11: Phase Two Reactions, cont.; Comparative Toxicology. Lecture 14 Slide
• Lecture 15; March 23: Comparative Toxicology, cont.- Species, Absorption, Distribution & Excretion Variations. Lecture 15 Slide
• Lecture 16; March 25: Comparative Toxicology, cont.- Strain/Genetic Variations; Physiological Factors in Toxicology cont.; Toxic Responses - Chemical Carcinogenesis
• Lecture 17; March 30: Toxic Responses - Chemical Carcinogenesis, cont. ; Teratogenesis.
• Lecture 18; April 1: Teratogenesis,cont.; Mutagenesis; Tissue Lesions.

Last modified 1April 2010

© RA Paselk 2008