Humboldt State University ® Department of Chemistry

Richard A. Paselk

Biochemical Toxicology

Chem 451		R. Paselk
Spring 2008	Lecture Notes	Office: SA560a
Office Hours: T 1000-1150, W 1600-1650, Th 1000-1050, F 1400-1450; other times by appointment		Phone: x 5719 Home: 822-1116
		e-mail: rap1

These are the notes I am using to present my lectures. They are here for the convenience of my students. They are unedited and thus liable to error. The expansions and corrections I put in during my lectures are not included. Use them at your own risk! If you find errors in my notes, please inform me ASAP via e-mail: rap1 @ axe.humboldt.edu

• Lecture 1; January 22: Introduction, What is Toxicology?
• Lecture 2; January 24: Biology Review; Cell Structure.
• Lecture 3; January 29: Cell Compartmentation; Membranes and Membrane Structure.
• Lecture 4; January 31: Proteins, Enzymes and Metabolism.
• Lecture 5; February 5: Dose-Response Relationships.
• Lecture 6; February 7: Dose-Response Curves - Quantitation of Dose-Response.
• Lecture 7; February 12: Quantitation of Dose-Response cont.
• Lecture 8; February 14: Absorption and Distribution: Factors Affecting Transport.
• Lecture 9; February 19: Absorption and Distribution, cont.: Effects of Ionization; Protein Binding.
• Lecture 10; February 21: Toxicokinetics.
• Lecture 11; February 26: Toxicokinetics, cont.; Excretion; Toxicant Metabolism - Phase One Reactions.
• Lecture 12; February 28: Phase One Monooxygenases - Example Reactions; P₄₅₀ mechanism.
• Lecture 13; March 4: Non- P₄₅₀ Oxidations; Reduction Reactions; Hydrolysis Reactions.
• Lecture 14; March 11: Phase Two Reactions.
• Lecture 15; March 13: Phase Two Reactions, cont.; Comparative Toxicology.
• Lecture 16; March 25: Comparative Toxicology, cont.- Species, Absorption, Distribution & Excretion Variations.
• Lecture 17; March 27: Comparative Toxicology, cont.- Strain/Genetic Variations; Physiological Factors in Toxicology.
• Lecture 18; April 1: Toxic Resposes - Chemical Carcinogenesis.
• Lecture 19; April 3: Toxic Resposes - Mutagenesis, Teratogenesis, Tissue Lesions.

Last modified 3 April 2008

© RA Paselk 2008