Kreb's TCA Cycle
- In what way can the cycle be considered catalytic for AcCoA
breakdown?
- Why is this elaborate system required to oxidize an acetyl
group?
- Can any other molecules be completely oxidized by the cycle?
- Why not? Know chemistry of reactions in cycle.
- What is strategy here?
- What is the "main line" sequence?
- Where is energy captured?
- as NADH?
- as FADH2?
- as GTP?
- Which reaction is irreversible?
- How is the cycle controlled?
- Be able to use the Kreb's Cycle and associated reactions
to oxidize any of the intermediates of the cycle.
- Know reactions interconverting Pyruvate, oxaloacetate and
PEP.
- Which of these reactions is regulated?
- How?
- Where do glutamate, alanine and aspartate enter the TCA Cycle?
(See metabolic interactions handout)
Review aerobic pathway energy generation:
- How many ATP equivalents are generated in the conversion
of glucose to CO2? KEY
- How many ATP equivalents are generated in the conversion
of pyruvate to CO2? KEY
- How many ATP equivalents are generated in the conversion
of lactatecytosol to CO2? KEY
- How many ATP equivalents are generated in the conversion
of alpha-Ketoglutaratemitosol to CO2? KEY
- How many ATP equivalents are generated in the conversion
of Oxaloacetatemitosol to CO2? KEY
©R A Paselk
Last modified 3 April 2013
