Humboldt State University ® Department of Chemistry

Richard A. Paselk

Chemistry 438 - Spring 2013

Pentose Phosphate Shunt (aka Hexose Monophosphate Shunt)

• How is pentose-P controlled?
  • How does control integrate it to biosynthesis?
    • Example: Assume that 40% of the reducing equivalents used in fatty acid biosynthesis come from the HMP Shunt:
      • If a cell makes fatty acid requiring a total of 550 reduction reactions, how many glucose molecules will be run through G-6-P DH? (ans: 110. Of course metabolism is not this straight-forward, but pretend!)

   

   

   

   

   

   

   

  Example: Assume that 50% of the reducing equivalents used in fatty acid biosynthesis come from the HMP Shunt and that each acetyl-CoA from glycolysis provides two C's for fatty acid biosynthesis:

  How many glucose molecules are needed to add 12 carbons to a fatty acid, assuming maximum incorporation into fatty acids? (ans: 3 1/2)

Schedule

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©R A Paselk

Last modified 3 April 2013