Humboldt State University ® Department of Chemistry

Richard A. Paselk

Chemistry 438 - Spring 2013

Give a pathway for the anaerobic breakdown of fructose to lactate, naming enzyme types and energy steps.

• fructose fructose 1-P (Aldolase)
• fructose 1-P glyceraldehyde + DHAP (Kinase) -1 ATP
• glyceraldehyde glyceraldehyde 3-P (Kinase) -1 ATP
• DHAP Ga-3-P (Isomerase)
• Ga-3P 1,3-bisPGA (DH) +1 NADH x 2
• 1,3-bisPGA 3-PGA (Kinase) +1 ATP x 2
• 3-PGA 2-PGA PEP (Mutase)
• PEP Pyruvate (Kinase) +1 ATP x 2
• Pyruvate Lactate (DH) -1 NADH x 2
  
  
• What is the net energy yield for this pathway in ATP units?
  • -2 ATP
  • -2 NADH x 3 ATP/NADH = -6 ATP
  • +4 ATP
  • +2 NADH x 3 ATP/NADH = +6 ATP
    • Total = +2 ATP

Schedule

C438 Home

C438 Lecture Notes

©R A Paselk

Last modified 3 April 2013