Chem 438 Lecture Notes, Spring 2013
These are the notes
I use to present my lectures. They are here for the convenience
of my students. They are unedited and thus liable to error. The
expansions and corrections I put in during my lectures are not
included. If you find errors in these notes, please inform me
ASAP via e-mail: rap1 @
axe.humboldt.edu
- Lecture 1; 23 January: Introduction;
What is Biochemistry? Elements of Life.
Lecture 1 slide
- Lecture 2;
25 January:
Elements of Life, cont.; Introduction to Biomolecules.
- Lecture 3;
28 January: Biomolecules, cont. Introduction to Thermodynamics in Metabolism.
- Lecture 4;
30 January: Introduction to Thermodynamics in Metabolism
cont.; Cells & Organelles. Lecture 4 slide
- Lecture 5;
1 February: Cells & Organelles, cont.; Introduction to Water. Lecture 5 slide
- Lecture 6;
4 February: Water—Ionic Properties; pH and Buffers. Lecture 6 slide
- Lecture 7;
6 February: Amino Acids—Structure, Side Chains, Properties. Lecture 7 slide
- Lecture 8;
8 February: Peptides and Proteins—Primary, Secondary and Tertiary Structure.
- Lecture 9;
11 February: Proteins—Tertiary - Quaternary Structure Hierarchy; Secondary and Tertiary Structure, including Motifs, Domains and Folds.
- Lecture 10;
13 February: Proteins—Domains, cont.; Quarternary Structure; IgG as Example Protein.
- Lecture 11;
15 February: Protein Folding; Myoglobin Structure.
- Lecture 12;
18 February: Myoglobin and Hemoglobin as Example Proteins; Oxygen Binding and Cooperativity.
- Lecture 13;
20 February: Introduction to Enzymes; Specificity; Enzyme Kinetics.
- Lecture 14;
22 February: Enzyme Kinetics, cont.; Enzyme Inhibition.
- Lecture 15;
25 February: Enzyme Inhibition cont.; Temperature and pH Effects on Rates; Introduction to Catalysis.
- Lecture 16;
27 February: Catalysis, cont.; Enyme Catalysis Examples. Lecture 16 slide
- Lecture 17;
1 March: Enyme Catalysis Examples, cont. Chymotrypsin; Introduction to Vitamins and Cofactors. Lecture 17 slide
- Lecture 18;
4 March: Vitamins and Cofactors, cont. Introduction to Carbohydrates, Disaccharides.
- Lecture 19;
6 March: Disaccharides and Polysaccharides, cont.; Introduction to Metabolism. Lecture 19 slide
-
Exam I: March 8
- Lecture 20;
11 March: Introduction to Metabolism, cont. High Energy Compounds; Introduction to Carbohydrate Metabolism. Lecture 20 slide
- Lecture 21;
13 March: Glycolysis I. Lecture 21 slide
- Lecture 22;
15 March: Glycolysis 2. Lecture 22 slide
- Lecture 23;
25 March: Glycolysis 3; Gluconeogenesis; Pentose Phosphate Pathway. Lecture 23 slide
- Lecture 24;
27 March: Glycogen Metabolism; Glycogen Control Cascade. Lecture 24 slide
- Lecture 25;
29 March: Pyruvate Metabolism; Kreb's TCA Cycle. Lecture 25 slide
- Lecture 26;
3 April: Aerobic Glucose Metablic Regulation; TCA Cycle Regulation; TCA Cycle Intermediate Metabolism; CHO Metabolism in Tissues etc. Lecture 26 slide
- Lecture 27;
8 April: Mitochodria; Introduction to Electron Transport. Lecture 27 slide
- Lecture 28;
10 April: Electron Transport and Oxidative Phosphorylation, cont. Lecture 28 slide
-
Exam II: April 12
- Lecture 29;
15 April: Mitochodrial Transport Systems; Introduction to Lipids. Lecture 29 slide
- Lecture 30;
17 April: Lipids, cont.; Membranes; Introduction to Lipid Metabolism. Lecture 30 slide
- Lecture 31;
19 April: Lipid Metabolism—beta-Oxidation of Fatty Acids; Ketone Body Biosynthesis. Lecture 31 slide
- Lecture 32;
22 April: Ketone Bodies – Ketogenesis; Fatty Acid Biosynthesis. Lecture 32 slide
- Lecture 33;
24 April: Fatty Acid Biosynthesis, cont.; Photosynthesis. Lecture 33 slide
- Lecture 34;
26 April: Photosynthesis Dark Reactions, cont.; C-4 Photosynthesis; Nitrogen Metabolism; Transaminases. Lecture 34 slide
- Lecture 35;
29 April: Pyridoxal-P, cont.; Urea Cycle; Tissue Distribution of AA Metabolism; Alanine Cycle. Lecture 35 slide
- Lecture 36;
1 May: Amino Acid Carbon Sketeton Metabolism; One-Carbon Pool. Lecture 36 slide
- Lecture 37;
3 May: Nucleotide Metabolism. Lecture 37 slide
- Lecture 38;
6 May: Metabolic Potpourri; Glyoxalate Cycle; Metabolic Integration. Lecture 38 slide
- Lecture 39;
8 May: Metabolic Integration, cont.–Exercise Metabolism. Lecture 39 slide
- Lecture 40;
10 May: Metabolic Integration, cont.–CHO Stress with Injury .
© R. A. Paselk 2010; Last modified 10 May 2013
Pathway Diagrams