Biosynthesis reactions for ketone body synthesis in teh liver

 

 

 

 

 

 

 

 

 

 

reduction of acetoacetate to give D-beta-hydroxybutyrate

 

 

 

 

 

 

 

 

 

 

 

 

 

oxidation of D-beta-hydroxybutyrate in the peripheral tissues

 

 

 

 

 

 

 

 

 

 

Reaction Energy Product Factor Multiplier ATP Equiv.
CoA transferase succinate (-GTP) 1 1 -1
Kreb's NAD+ DH's NADH 2.5 x 3 2 15
Kreb's GTP 1 2 2
Kreb's FADH DH FADH2 1.5 2 3

Acetoacetate Total:

19
Butyrate DH NADH 2.5 1 2.5

Butyrate Total:

 21.5

 

 

 

 

 Compound \ Tissue Liver Peripheral Tissues
3-hydroxybutyrate 17% 83%
Acetoacetate 26% 74%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Acetyl-CoA carboxylase reaction

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Fatty acyl synthase

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Fatty acyl synthase reactions

 

 

 

© R. A. Paselk 2010; Last modified 19 April 2013