Integrated Regulation of Aerobic Glucose Metabolism

 

 

 

 

 

 

 

 

 

 

 

 

 

Kreb's TCA Cycle reactions and structures

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Kreb's Cysle intermediate catabolism pathway diagram

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Data from E. A. Newsholme and A. R. Leach Biochemistry for the Medical Sciences. John Wiley & Sons, New York (1983) pp 101 & 110.

 Enzyme Substrate Substrate Conc. (mM)  Km (mM) DeltaG (kJ/mol)  Effectors
 Citrate synthase acetyl-CoA 100-600 5-10 -53.9
Succinyl CoA (-), ATP (-), NADH (-)
oxaloacetate 1-10 5-10
 Isocitrate DH (NAD+) isocitrate 150-700 50-200 -17.5
 Ca2+ (+), ATP (-), ADP(+), NADH (-)
 2-Oxoglutarate DH 2-oxoglutarate 600-5900 60-200 -43.9
 Ca2+ (+), Succinyl CoA (-), NADH (-)

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

diagram of the metabolic pathways for glucose in human tissues

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Glycolysis/Gluconeogenesis Interactions diagram

 

 

 

© R. A. Paselk 2010; Last modified 3 April 2013