Chem 438 Lecture Notes, Spring 2012
These are the notes
I use to present my lectures. They are here for the convenience
of my students. They are unedited and thus liable to error. The
expansions and corrections I put in during my lectures are not
included. If you find errors in these notes, please inform me
ASAP via e-mail: rap1 @
axe.humboldt.edu
- Lecture 1; 18 January: Introduction;
What is Biochemistry? Elements of Life.
- Lecture 2;
20 January: Biomolecules; The Cellular Basis of Life.
-updated 1/25
- Lecture 3;
23 January:
Cells and Cell Structure and Function. Lecture 3 Slide
- Lecture 4;
25 January:
Water Lecture 4 Slide
- Lecture 5;
27 January:
Water - Osmosis; Ionization & Buffers.
- Lecture 6;
30 January:
Thermodynamics and Metabolism.
- Lecture 7;
1 February:
ATP and Reaction Coupling; Introduction to Amino Acids.
- Lecture 8;
3 February:
Amino Acids - Side Chains, Properties, and Peptide Formation; Ramachandran Diagrams.
- Lecture 9;
6 February:
3-D Protein Structure 1, Primary - Domains.
- Lecture 10;
8 February:
3-D Protein Structure 2, Domains & Quaternary Structure; Protein Denaturation and Folding.
- Lecture 11;
10 February:
Protein Folding, cont.; Myoglobin (Mb) and Hemoglobin (Hb) as Example Proteins.
- Lecture 12;
13 February:
Mb and Hb Oxygen Binding; Introduction to Enzymes.
- Lecture 13;
15 February:
Enzyme Kinetics - MM Equation.
- Lecture 14;
17 February:
Enzyme Kinetics -Linear Ploting; Enzyme Inhibition; Effects of Temperature and pH on Rates.
- Lecture 15;
20 February:
Enzyme Catalysis - Chemical Models for Catalysis; Lysozyme Mechanism.
- Lecture 16;
22 February:
Allosterism and Enzyme Regulation; Introduction to Carbohydrates.
- Lecture 17;
24 February:
Carbohydrate Chemistry; Carbohydrate Polymers.
- Lecture 18;
27 February:
Introduction to Metabolism; Carbohydrate Metabolism 1.
Lecture 18 Slide
- Lecture 19;
29 February:
Glycolysis II - Energetics, Phase I Reactions. Lecture 19 Slide
- Exam I; 2 March
- Lecture 20;
5 March:
Return Exam 1; Glycolysis 3 - Phase II Reactions. Lecture 20 Slide
- Lecture 21;
7 March: Glycolysis 4 - Redox Balance; Gluconeogenesis; Pentose Phosphate Pathway. Lecture 21 Slide
- Lecture 22;
9 March: Glycogen Metabolism; Glycogen Control Cascade; Pyruvate Dehydrogenase Complex. Lecture 22 Slide
- Lecture 23;
19 March: Kreb's TCA Cycle. Lecture 23 Slide
- Lecture 24;
21 March: Kreb's TCA Cycle, cont. – Intermediate Catabolism, Regulation; CHO Metabolism in Tissues, Metabolism of Non-Glucose Sugars. Lecture 24 Slide
- Lecture 25;
23 March: Mitochodrial Electron Transport System; Energy and Electron Potentials; the Electron Transport System. Lecture 25 Slide
- Lecture 26;
26 March: Oxidative Phosphrylation-Making ATP from the the Chemiosmotic Gradient; Mitochondrial Transport/Communication; Regulation of ETS/OxPhos. Lecture 26 Slide
- Lecture 27;
28 March: Lipids; Lipid Bilayers and Membranes. Lecture 27 Slide
- Lecture 28;
2 April: Lipid Metablism 1 - Beta-Oxidation of Fatty Acids. Lecture 28 Slide
- Lecture 29;
4 April: Lipid Metablism 2 - Ketone Bodies & Ketone Body Metabolism: Introduction to Fatty Acid Biosynthesis. Lecture 29 Slide
- Exam II; 6 April
- Lecture 30;
9 April: Lipid Metablism 2 - Fatty Acid Biosynthesis, cont.; Pyruvate-Malate Shuttle; Integrated Biosynthesis of FA from Glucose. Lecture 30 Slide
- Lecture 31;
11 April: Control of FA Metabolism; Photosynthesis. Lecture 31 Slide
- Lecture 32;
13 April: Photosynthesis, cont.– Calvin Cycle Flow Diagram, C4-Photosynthesis; Introduction to Nitrogen Metabolism. Lecture 32 Slide
- Lecture 33;
16 April: Nitrogen Metabolism, cont. - Aminotransferase Reaction and Mechanism; Urea Cycle; Tissue Distribution of Amino Acids. Lecture 33 Slide
- Lecture 34;
18 April: Alanine Cycle; Catabolism of Amino Acid Carbon Skeletons. Lecture 34 Slide
- Lecture 35;
20 April: The One -Carbon Pool. Lecture 35 Slide
- Lecture 36;
23 April: Nucleotide Metabolism. Lecture 36 Slide
- Lecture 37;
25 April: Metabolic Integration - Overview; Carbohydrate Stress in Starvation and Exercise. Lecture 37 Slide
- Lecture 38;
27 April: Metabolism in Exercise; Glyoxalate Cycle. Lecture 38 Slide
- Lecture 39;
30 April: Metabolic Integration: Text Slides from Lipid Metabolism Chapter (Fig.12.1, 2, 3, 4, 5, 22, 23, 24); Review of Hypogltcemia Case Study.
- Lecture 40;
2 May: No Lecture Meeting—Homework Assignment, Make up Data/Information Sheet and bring it to Friday meeting.
- Lecture 41;
4 May: Review for Final.
© R. A. Paselk 2010; Last modified 30 April 2012
Pathway Diagrams