Chem 438 Lecture Notes, Spring 2011
These are the notes
I use to present my lectures. They are here for the convenience
of my students. They are unedited and thus liable to error. The
expansions and corrections I put in during my lectures are not
included. If you find errors in these notes, please inform me
ASAP via e-mail: rap1 @
axe.humboldt.edu
- Lecture 1; 19 January: Introduction;
What is Biochemistry? Elements of Life.
- Lecture 2; 21 January: Molecules of Life. Lecture 2 Slide
- Lecture 3; 24 January: Origin and Early Evolution of Life; Cells and Organelles, Prokaryotes. Lecture 3 Slide
- Lecture 4; 26 January: Cells and Organelles, Eukaryotes; Introduction to Vitamins. Lecture 4 Slide
- Lecture 5; 28 January: Introduction to Vitamins, cont.;Water. Lecture 5 Slide
- Lecture 6; 31 January: Water, cont.; Ionic Properties of Water. Lecture 6 Slide
- Lecture 7; 2 February: Amino Acids, Properties and Side Chains (Uncharged). Lecture 7 Slide
- Lecture 8; 4 February: Amino Acids, cont.: Polar and Charged Side Chains; pKas of Amino Acids; Peptides, Protein Structure. Lecture 8 Slide
- Lecture 9; 7 February: Protein Structure, cont., Peptide Titration; Protein Secondary Structure.
- Lecture 10; 9 February: Protein Structure 3, Protein Supersecondary (Motif), Domain, and Tertiary Structures.
- Lecture 11; 11 February: Protein Structure 4, Quaternary Structures; Protein Folding. Lecture 11 Slide
- Lecture 12; 14 February: Protein Folding, cont.; Myoglobin and Hemoglobin as Model Proteins; Oxygen Binding.
- Lecture 13; 16 February: Hemoglobin as Model Proteins–Allosteric Binding and Regulation; Models of Allosteric Regulation.
- Lecture 14; 18 February: Introduction to Enzymes; Specificity; Kinetics.
- Lecture 15; 21 February: Enzyme Kinetics, cont.; Enzyme Inhibition. Lecture 15 Slide
- Lecture 16; 23 February: Enzyme Kinetics, cont.; Effects of Temperature and pH on Rates; Enzyme Catalysis: Introduction, General Acid/Base. Lecture 16 Slide
- Lecture 17; 25 February: Enzyme Catalysis, cont.: Covalent, Proximity/Orientaiton, Strain/Distortion, Metal; Enzyme Examples. Lecture 17 Slide
- Lecture 18; 28 February: Introduction to Carbohydrates. Lecture 18 Slide
- Lecture 19; 2 March: Carbohydrates, cont., Polysaccharides; Introduction to Lipids.
- Exam 1; March 4
- Lecture 20; 7 March: Lipids, cont; Biological Membranes; Introduction to Metabolism.
Lecture 21; 9 March: Introduction to Metabolism.
Lecture 21 Slide
- Lecture 22; 11 March: Introduction to Metabolism, cont. - Thermodynamics in Metabolism; Glycolysis. Lecture 22 Slide
- Lecture 23; 21 March: Glycolysis 2, Thermodynamics and Phase 1 Reactions. Lecture 23 Slide
- Lecture 24; 23 March: Glycolysis 3, Energy Charge; Phase 2 Reactions; Cleland Multisubstrate Kinetic Enzyme Mechanisms. Lecture 24 Slide
- Lecture 25; 25 March: Glycolysis 4, Phase Three reactions; Gluconeogenesis; Pyruvate Metabolism. Lecture 25 Slide
- Lecture 26; 28 March: Kreb's TCA Cycle. Lecture 26 Slide
- Lecture 27; 30 March: Kreb's TCA Cycle & Glucose Catabolism, cont.; Glycogen Metabolism and Control. Lecture 27 Slide
- Lecture 28; 1 April: Glycogen Metabolism, cont.; Glycogen Metabolism Control; Pentose Phosphate Pathway. Lecture 28 Slide
- Lecture 29; 4 April: Glucose in Tissues: Other Sugars; Mitochondrial Electron Transport. Lecture 29 Slide
- Lecture 30; 6 April: Mitochondrial Electron Transport System, cont. Lecture 30 Slide
- Exam 2; April 8
- Lecture 31; 11 April: Mitochondrial Transport/Communication; Introduction to Fat Metabolism. Lecture 31 Slide
- Lecture 32; 13 April: Fat Metabolism, cont., beta-Oxidation of Fatty Acids. Lecture 32 Slide
- Lecture 33; 15 April: Ketone Bodies; Fatty Acid Biosynthesis. Lecture 33 Slide
- Lecture 34; 18 April: Fatty Acid Biosynthesis; FA Metabolic Control. Lecture 34 Slide
- Lecture 35; 20 April: Introduction to Nitrogen Metabolism; Transamination. Lecture 35 Slide
- Lecture 36; 22 April: Urea Cycle; Tissue Distribution of Amino Acid Catabolism; Alanine Cycle. Lecture 36 Slide
- Lecture 37; 25 April: Catabolism of Amino Acid Carbon Skeleton; the One-Carbon Pool. Lecture 37 Slide
- Lecture 38; 27 April: The One-Carbon Pool, cont.; Photosynthesis. Lecture 38 Slide
- No Lecture 29 April – Work on Hypoglycemia CS
- Lecture 39; 2 May: Photosynthesis, cont. Lecture 39 Slide
- Lecture 40; 4 May: Photosynthesis, cont.- C4; Metabolic Integration; Carbohydrate Stress. Lecture 40 Slide
- Lecture 41; 6 May: Metabolism in Exercise. Lecture 41 Slide
© R. A. Paselk 2010; Last modified 6 May 2011
Pathway Diagrams