Glycolysis Pathway diagram

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Aldolase: F-1,6-bis P to Glyceraldehyde-3-Phosphate & Dihydroxyacetone Phosphate

Structural diagram for aldolase reaction

 

 

 

 

 

 

 

 

 

 

 

 

Aldol condensation mechanism

Structural diagram for aldol cleavage mechanism

 

Structural diagram for alpha carbon resonance

 

 

 

 

 

 

 

 

 

 

 

 

 

 

The molecular mechanism for type I Aldolase

Structural diagram for the molecular mechanism of type 1 aldolases

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Kinetic Mechanisms

ordered sequential Bi Bi Kinetic mechanism diagram

Ordered Sequential Bi Bi

Random Sequential Bi Bi Kinetic mechanism diagram

Random Sequential Bi Bi

Ping Pong Bi Bi Kinetic mechanism diagram

Ping pong Bi Bi

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Aldolase Ordered Sequential Uni Bi kinetic mechanism:

Ordered Sequential Uni Bi Kinetic mechanism diagram for aldolase

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Triose Phosphate Isomerase: DHAP to GA-3-P

Structural diagram for triose phosphate isomerase reaction

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Glyceraldehyde 3-Phosphate Dehydrogenase: GA-3-P to 1,3-bis PGA

Structural diagram for glyceraldehyde 3-phosphate dehydrogenase reaction

 

 

 

 

 

 

 

 

GA-3-P DH shows an Ordered Sequential Ter Bi kinetic mechanism:

 

 

 

 

 

 

 

 

 

 

 

 

 

Simplified Molecular Mechanism

simplified molecular mechanism for Ga-3-P DH

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Structural diagram for the molecular mechanism of Ga-3-P DH

simplified molecular mechanism for Ga-3-P DH

 

 

 

 

 

 

 

 

 

 

Phosphoglycerate Kinase: 1,3-bis PGA to 3-PGA

Structural equation for Phosphoglycerate Kinase

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Phosphoglycerate Mutase: 3-PGA to 2-PGA

Structural equation for PGA mutase

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

PGA Mutase Mechanism

3-PGA + E-P equilibrium arrows 2,3-bisPGA + E equilibrium arrows 2-PGA + E-P

 

Molecular mechanism for PGA Mutase

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Enolase: 2-PGA to PEP

Structural equation for Enolase

 

 

 

 

 

 

 

 

 

 

 

 

 

Enolase alcohol elimination reaction mechanism

Molecular mechanism for Enolase

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Pyruvate Kinase: PEP to Pyruvate

Structural equation for Pyruvate kinase reaction

 

 

 

 

 

 

 

 

 

 

 

 

 

Molecular mechanism for PK (simplified)

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Lactate DH

Structural equation for Lactate DH reaction

 

 

 

 

 

 

 

 

 

 

 

 

 

Simplified molecular mechanism for Lactate DH

 

 

 

 

Last modified 5 April 2010