Glycolysis Pathway diagram

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Table I. Free energies, apparent equilibrium constants, mass action ratios, and maximum enzyme activities (in micromol S transformed/min/g fresh tissue) for glycolytic enzymes (Adapted from Newsholme and Start, Regulation in Metabolism, Wiley (1973)).

Glycolytic Enzymes . . Brain . Skeletal Muscle . RBC .
. DeltaG°', kJ K' Q Max Act Q Max Act Q Max Act
Hexokinase -21.94 5000 0.04 17 - 1.5 0.00076 0.3
Hex.Isomerase 2.36 0.4 0.22 80 - 176 0.41 5.6
PFK -17.80 1000 0.13 24 - 56 0.044 1.8
Aldolase 23.73 0.0001 0.000002 15 - 78 0.000014 0.7
Triose Isom. 8.29 0.04 - 415 - 2650 0.35 97
GAP DH - - - 105 - 440 - 17.1
PGA K - - - 610 - 169 - 25.6
DH+K -17.22 800 53 - - - 124 -
Mutase 4.89 0.15 0.1 122 - 100 0.15 8.6
Enolase -3.23 3.5 3.6 47 - 158 1.7 1.6
Pyr K -23.73 10000 5.4 164 - 387 51 4.6
Lac. DH - - - 100 - 366 - 20.4

 

 

 

 

 

 

 

 

 

 

 

 

 

 

bar chart of glycolysis reaction free energies

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Hexokinase (HK): Glucose to G-6-P

Structural diagram for the hexokinase reaction

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Structural diagram for the chemical mechanism of the hexokinase reaction

 

 

 

 

 

 

 

 

 

 

 

 

 

G-6-P Isomerase: G-6-P to F-6-P

Structural diagram for the G-6-P isomerase reaction

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Lobry-de-Bruyn von Ekenstein mechanism

Structural diagram for the Lobry de Bruyn mechnism

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

PhosphoFructoKinase (PFK)-1: F-6-P to F-1,6-bis P

Structural diagram for the PFK reaction

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Energy Charge

mathematical expression for energy charge

Plot of energy charge vs. the relative rates of anabolism and catabolism

 

 

 

 

 

 

 

 

 

Last modified 29 March 2010