Humboldt State University ® Department of Chemistry

Richard A. Paselk

Chem 438

Introductory Biochemistry

Spring 2010

Lecture Notes: 12 February

© R. Paselk 2006


3-D Structure of Proteins 3

Secondary Structure/Motifs, cont.

Aside: Fibrous proteins, cont:

Non-repetitive secondary elements: Proteins can also have non-repetitive secondary structures which consist of a few residues in a turn or loop. Among these are:

Tertiary Structures

The Tertiary structure describes the overall folding of a single covalent structure.

As the number of known protein structures increased additional patterns became obvious within the tertiary level of structure: Motifs & Domains.

Quaternary Protein Structure

Quaternary (4°) structures (Fig. 4.25; overheads: MvH 6.26, Fig 25): Geometrically specific associations of protein subunits; the spatial arrangement of protein subunits.

Rationale for quaternary: There are a variety of advantages to large structures:

Quaternary structures allows the assembly of large to extremely large structures. 

Folding Hierarchy Overview

Let's look at how the various levels of structure go ingto making a typical multimeric protein:

diagram of protein folding hierarchy

Pathway Diagrams

C438 Home

Lecture Notes

Last modified 14 February 2010