Chem 438 Lecture Notes, Spring 2007
These are the notes
I use to present my lectures. They are here for the convenience
of my students. They are unedited and thus liable to error. The
expansions and corrections I put in during my lectures are not
included. If you find errors in these notes, please inform me
ASAP via e-mail: rap1 @
axe.humboldt.edu
- Lecture 1; 17 January: Introduction;
What is Biochemistry? Elements of Life.
- Lecture 2; 18 January: Elements of Life, cont. Biomolecules.
- Lecture 3; 22 January: Origin and Early Evolution of Life; Introduction to Cells.
- Lecture 4; 24 January: Cell Organelles; Introduction to Water.
- Lecture 5; 25 January: Water.
- Lecture 6; 29 January: Water Ionization, Acids, Bases, and Buffers; Amino Acids 1.
- Lecture 7; 31 January: Amino Acids 2, Side Chains and Chemistry.
- Lecture 8; 1 February: Peptide Bonds & Primary Protein Structure; 3-D Protein Structure.
- Lecture 9; 5 February: 3-D Protein Structure 2 - Secondary Structures.
- Lecture 10; 5 February: 3-D Protein Structure 3 - Collegen; Tertiary Structures, Motifs and Domains.
- Lecture 11; 8 February: 3-D Protein Structure 4 - More on Domains; Quaternary Structures; Introduction to Protein Folding.
- Lecture 12; 12 February: Protein Folding, cont.; Myoglobin and Hemoglobin as Example Proteins.
- Lecture 13; 14 February: Myoglobin and Hemoglobin - Oxygen Binding; Allosterism and Regulatory Proteins.
- Lecture 14; 15 February: Enzyme Specificity; Michaelis-Menten Enzyme Kinetics.
- Lecture 15; 19 February: Enzyme Kinetics and Inhibition, M-M and L-B Plots; Effects of Temperature and pH on Rates.
- Lecture 16; 21 February: Enzyme Catalysis - Model Catalytic Systems.
- Lecture 17; 22 February: Enzyme Catalysis - Examples; Introduction to Carbohydrates.
- Lecture 18; 26 February: Carbohydrates, cont. - Hexoses; Disaccharides.
- Lecture 19; 28 February: Carbohydrates, cont. - Polysaccharides; Introduction to Lipids.
- Lecture 20; 1 March: Carbohydrates, cont. - Polysaccharides; Introduction to Lipids.
- Lecture 21; 5 March: Membrane Biogenesis/Protein Targeting; Introduction to Vitamins and Cofactors.
- Lecture 22; 7 March: Vitamins and Cofactors, cont.; Introduction to Metabolism.
- Lecture 23; 8 March: Metabolic Pathways; High Energy Compounds.
- Lecture 24; 19 March: Introduction to Thermodynamics.
- Lecture 25; 21 March: Thermodynamics and Metabolism; Glycolysis Overview.
- Lecture 26; 22 March: Glycolysis - Phase One Reactions.
- Lecture 27; 26 March: Glycolysis - Phase Two Reactions; Aldolase and Glyceraldehyde-3-P Dehydrogenase Mechanisms; Cleland Nomenclature for Multisubstrate Enzymes.
- Lecture 28; 28 March: Glycolysis - Phase Three Reactions; Pyruvate Regeneration; Introduction to Gluconeogenesis.
- Lecture 29; 29 March: Gluconeogenesis 2; Pyruvate Metabolism; Introduction to Kreb's TCA Cycle.
- Lecture 30; 2 April: Kreb's TCA Cycle; Aerobic Metabolism of Glucose and TCA Cycle Intermediates.
- Lecture 31; 4 April: Glycogen Metabolism and Control; Pentose Phosephate Pathway, the Oxidative Reactions.
- Lecture 32; 5 April: Pentose Phosephate Pathway, Sugar Interconversions; Energy and Reduction Potentials.
- Lecture 33; 9 April: Energy and Reduction Potentials; Electron Transport System.
- Lecture 34; 11 April: Oxidative Phosphorylation; Mitochondrial Transport/Communication; Regulation of ETS/OxPhos.; Introduction to Fat Metabolism.
- Lecture 35; 12 April: beta-Oxidation of Fatty Acids.
- Lecture 36; 16 April: Ketone Bodies; Fatty Acid Biosythesis.
- Lecture 37; 19 April: Integration of Fatty Acid Biosynthesis; Introduction to Nitrogen Metabolism.
- Lecture 38; 19 April: Deamination and Transamination of Amino Acids.
- Lecture 38; 19 April: Deamination and Transamination of Amino Acids.
- Lecture 39; 23 April: Kreb's Urea Cycle; Tissue Distribution of Amino Acid Catabolism; Amino Acid Carbon Metabolism.
- Lecture 40; 25 April: Amino Acid Carbon Metabolism, cont.; The One-Carbon Pool.
- Lecture 41; 29 April: Photosynthesis - Light Reactions; Dark Reactions; C-4 Reactions.
- Lecture 42; 29 April: Metabolic Integration; Carbohydrate Stress.
- Lecture 43; 29 April: Metabolic Integration, cont.
Last modified 3 May 2007
Pathway Diagrams