 Pathway Diagrams |
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| Chem432 |
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Sp 2002 |
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The final will consist of two parts: 1) the ACS Standardized Biochemistry Final [about 60 questions, 1-2 hrs in length], and 2) a short supplemental exam with questions covering the student seminars and the materials below.
Translation: Ribosomes: Describe, compare and contrast the ribosomes of E. coli and mammals. What are the functions of the ribosome. Polypeptide synthesis: Proceeds from NÆC terminus, m-RNA read 5'Æ3' (same as direction of m-RNA synthesis). Polysome. What are the three stages of peptide synthesis? Diagram the process of peptide synthesis (as in fig 30-40, 41, & 43 in Voet & Voet) with brief explanatory comments where necessary for clarity. Review various aspects of post-translational modification of proteins as exemplified by collagen and insulin. What are the functions of protein degradation? How do eukaryotes and prokaryotes differ? Why?
Class Discussions:
- What are the two common strategies for vaccines against viruses?
- In what sense has the work of Shiver et. al. demonstrated an effective vaccine strategy?
- How does the work reported by Barouch et. al. impact the developments reported by Shiver et. al.?
- What does this article say about the AIDS infection and controlling it via vaccines?
- How did the virus respond to the vaccine?
- What was the final result of the vaccination for the course of the disease?
- What problems does the infection/disease progress model used by these groups have for developing a vaccine for human AIDS?
A data/information sheet is not allowed for this exam.
| Pathway Diagrams |
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Last modified 10 May 2002
