Gluconeogenesis and Glycolytic Control
- Know the major branch points and entry points for sugars
in carbohydrate metabolism (see metabolism handouts):
- Know the "bypass" reactions of gluconeogenesis.
- How is glycolysis/gluconeogenesis linked to Kreb's Cycle?
- What is a futile cycle?
- Is a futile cycle always futile or can it be useful?
- Know how glycolysis/gluconeogenesis controlled.
- Note the hierarchy of control.
- In what senses does PFK function as the main and most important
control enzyme in glycolysis.
- Know what substances act as effectors for PFK and how they
- Why is AMP used as the physiological regulator of PFK activity
in advanced organisms (modern bacteria - eukaryotes)
- Know how PFK activity indirectly affects the activities of
the other control enzymes of glycolysis/gluconeogenesis.
- Be able to discuss in detail the regulation of carbohydrate
metabolism and, in particular, the regulation of PFK.
©R A Paselk
Last modified 13 November 2008