Humboldt State University ® Department of Chemistry

Richard A. Paselk

Chem 431

Biochemistry

Fall 2008

Lecture Notes: 27 October

© R. Paselk 2008
 
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Membrane Assembly/Protein Targeting

Assembly occurs on scaffolding of previous membrane

Membrane lipids are synthesized in/on membrane (Eukaryotes synthesis on cytosolic face of ER, transport by budding and Phospholipid exchange protein.

Proteins in cytosol, and those targeted to mitochondria are synthesiszed on cytosolic polysomes (text Figure 27-32a). Signal hypothesis for targeting of many membrane and exported proteins:

Proteins are transported in coated vesicles: membranous sacs encased in polyhedral frameworks of clathrin. (text Figure 27-40ab, 27-40c)

Introduction to Vitamins and Cofactors

Terms:

Let's start with a brief overview of the names, structures and physiological functions of the common vitamins as shown on the overhead: Niacin, Riboflavin [B2], Thiamine, Pantothenic acid, Biotin, Pyridoxal [B6], Folic acid, Lipoic acid, Cobalamin [B12], L-Ascorbic acid [C], and the lipid soluble vitamins A, D, E, and K). Fun facts:

Fun facts:


Pathway Diagrams

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Last modified 28 October 2008