Chem 431 Lecture Notes
These are the notes I am using to present
my lectures. They are here for the convenience of my students.
They are unedited and thus liable to error. The expansions and
corrections I put in during my lectures are not included. Use
them at your own risk!
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@ axe.humboldt.edu
Errors corrected for Oct 31 and Nov
2 & 5
- August 29: Introduction.
- August 31: Types of Biomolecules;
Origin of Life, Pre-Cambrian Life.
- August 31: Cells, Organelles,
and Metabolic Compartmentation.
- September 5: Thermodynamics in
Biology; Water.
- September 7: Water, cont.: Ice;
Ionization, Buffers. Nitrogenous Bases.
- September 10: Nucleic Acids;
Introduction to Amino Acids.
- September 12: Amino Acid Side
Chains.
- September 14: Peptides &
Protein Primary Structure; Overview of Protein 3-D Structure;
Secondary Structure.
- September 17: 3-D Protein Structure
II - Secondary Structures, Tertiary Structures, Domains, &
Motifs.
- September 19: Silk Fibroin;
Domains & Exons; Protein Quaternary Structure.
- September 21: Hierarchy of Protein
Structure; X-ray Structures and Reality; Protein Folding.
- September 24: Protein Folding,
cont.; Protein Dynamics and "Breathing." Myoglobin
Oxygen Binding.
- September 26: Oygen Binding
by Hb, Hill Equation and Plot; Mb & Hb as Model Proteins;
Allosterism.
- September 28: Carbohydrates
I.
- October 1: Carbohyderates II:
Polysaccharides.
- October 3: Lipids.
- October 5: Membranes; Introduction
to Enzymes.
- October 8: Enzyme Specificity;
Introduction to Enzyme Kinetics.
- October 10: Enzyme Kinetics,
cont.; Introduction to Enzyme Inhibition.
- October 15: Enzyme Inhibition;
Bi-substrate Reaction Kinetics.
- October 17: Temperature and
pH Effects on Enzymes; Molecular Mechanisms of Catalysis.
- October 19: Molecular Mechnisms
of Catalysi, cont.; Enzyme Catalysis.
- October 22: Vitamins and Cofactors.
- October 24: Introduction to
Metabolism.
- October 26: ATP & High Energy
Compounds; Digestion; Glycolysis 1.
- October 29: Glycolysis 2 - Free
Energy and Equilibria in Glycoysis, Glycolysis Stage I Reactions.
- October 31: Glycolysis 3 - Aldolase
- PGA Mutase.
- November 2: Glycolysis 4 -Finish;
Glycogen Synthesis.
- November 5: Glycogen Control
Cascade; Gluconeogenesis.
- November 7: Gluconeogenesis
2; Glycolysis Control; Introduction to Pentose Phosphate Pathway;
Pentose-P Oxidative Reactions.
- November 9: Pentose Phosphate
Pathway - the Interconversions; Pyruvate Metabolism; Introduction
to the Kreb's Cycle.
- November 12: Kreb's Cycle -
Reactions and Energy Production.
- November 14: Regulation and
Control of the Kreb's Cycle; Kreb's Intermediate Metabolism;
Introduction to the ETS.
- November 26: Mitochondrial Electron
Transport - Redox Potentials; Overview; Review of Redox Components.
- November 28: Mitochondrial Electron
Transport - Proton Gradient Formation; Oxidative Phosphorylation.
- November 30: Mitochondrial Transport/Communication;
Photosynthesis - the Light Reactions.
- December 3: Photosynthesis -
the Dark Reactions (Calvin's Cycle).
- December 5: Introduction to
Fat Metabolism; b-Oxidation of Fatty
Acids.
- December 7: Fat Metabolism 2
- Ketone Bodies.
- December 10: Fat Metabolism
3 - Fatty Acid Biosynthesis; Pyruvate-Malate Cycle & Integration
with CHO's; FA Elongation.
- December12: Fatty Acid Desaturation;
Nitrogen Metabolism - Introduction & Transaminase Reactions.
- December 14: Last Lecture! Amino
Acid Metabolism: Kreb's Urea Cycle; Tissue Distribution of Amino
Acid Catabolism; Alanine Cycle; Amino Acid Carbon Catabolism.
Last modified 14 December 2001
Pathway Diagrams