Biology 105 Principles of Biology Spring 2008

Instructor: Dr. Mark S. Wilson. teaches lecture, Mon 11-2 and W 2-5 lab.

Office: SB 222; phone 826-5557 (includes voicemail), email: msw13@humboldt.edu

Note: email is quickest way to get in touch; voicemail is sometimes delayed 24 hours

TA: Andrea Bartles (anb1) teaches R 11-2 lab

Office Hours: My tentative office hours are M (2-3) T/R (2-3), W (12-1). If you can't make these times, I'm happy to arrange additional appointment times to fit your schedules. If you drop in without an appointment, I cannot guarantee that I will have time to meet with you.

Lecture: Tues and Thurs 4-5:20 pm in SB135

Lab: M 11-2, W 2-5; R 11-2. all labs meet in ScB 132

Required Text: Biology. 1st edition. 2007. Brooker, Robert J. (McGraw-Hill, publisher)

ISBN-10: 0073268070 # ISBN-13: 978-0073268071

The lab manual is available free online on the Moodle site for this course.

you need to read and print out labs before the first lab meeting

Moodle : Moodle (http://learn.humboldt.edu/) is a course management web site. I will post lecture notes and some other copyrighted material to the BIO105 Moodle site for your use.

Overview: BIO105 is designed to be an introduction to biology for students majoring in the sciences, in particular the biological sciences and related fields. CHEM 105, CHEM 107, or CHEM 109 (with a grade of C or better) is a prerequisite for this course. Biology is a very broad discipline and we will be focusing on subjects that are of universal applicability for students majoring in diverse fields. Areas of emphasis include: the scientific process, molecular principles of cellular and subcellular processes, heredity, and evolution. Major concepts in these fields will be discussed in lectures and readings while laboratory exercises are designed to allow you to gain hands-on experience in biological experimentation.

Grading: A total of 800 points can be earned in this class, distributed as follows:

Lecture	Exam 1	100
	Exam 2	100
	Exam 3	100
	Final Exam (cumulative)	200
Laboratory	Exams & Quizzes	100
	Assignments (5)	150
	Notebook	40
	participation, etc... (see below)	35

If you earn the following percentage of the total points, you are assured of these grades: 90% or more , A-; 80% or more, B-; 70% or more, C-; 60% or more, D. Do not count on generous 'grade curves' for this course. Lecture exams will cover the material presented in lectures, labs, and in your assigned readings (see below). The final exam will be cumulative, with emphasis on material covered after the third exam. Exams and quizzes must be taken during the scheduled time unless extraordinary circumstances exist--any exceptions must be pre-arranged with the instructor. Similarly, missed labs cannot be made up unless pre-arrangements are made.

Tentative Lecture Schedule

Readings are page numbers from Brooker first edition.

Week	Lecture Topics	Reading
1 (1/21)	Introduction: Science as a way of knowing Scientific Method cont'd....begin chemistry	1-19, handouts 21-33
2 (1/28)	Water Chemistry Carbon in all its glory! Biological Macromolecules	33-39 41-44 44-59
3 (2/4)	Cell structure / function	Chapters 4-6
4 (2/11)	Membrane Structure/function	Chapter 5
5 (2/18)	Exam #1 - Tuesday, 2-18-08 (material thru 2-12-08) Metabolism & Enzyme function	125-134
6 (2/25)	How food works - glycolysis and respiration Photosynthesis	134-145 Chapter 8
7 (3/3)	Photosynthesis (continued) Cell communication and Signal Transduction	171-182
8 (3/10)	Cell cycle/ DNA structure Exam #2 – Thursday, 3-13-08 (material thru 3-6-08)	185-189,213-219
9 (3/17)	Spring Break
10 (3/24)	DNA replication Transcription - (making mRNA from DNA) Translation (making protein from mRNA)	219-228 231-252
11 (3/31)	Gene regulation	256-276
12 (4/7)	Chromosome structure/Mitosis/Meiosis Transmission (Mendelian) genetics	299-323 325-352
13 (4/14)	Transmission (Mendelian) genetics Exam #3 - Thursday, 4-17-08 (thru 4-10)
14 (4/21)	Natural selection and evolution	Chap. 23
15 (4/28)	Evolution and populations Microevolution and natural selection	Chap. 24 - 25
16 (5/5)	Species/Speciation Ecology-and ecosystems	Chap. 26 Chapter 54
Final 5/13	Final Exam, Tues 5-13-08, from 3:00 - 4:50 pm

General Laboratory Guidelines – lab manual is on course Moodle site

Before the first lab class: Before coming to your first lab, you should print out and read the 'Introduction to BIO105' section (all headings except 'Preparing the Group Scientific Report'), and the 'Lab procedures and Safety' section. Because we will be performing the experiments in sections 'A: Care and Use of the Microscope' and 'B: The Cell', you are also required to have read these sections and to bring a printed copy of those sections with you to the first lab period. You also need to get a three ring binder in which you put each section of the lab manual into (see lab notebook, below).

Before every class: You are required to have read the assigned exercises prior to coming to lab each week, and you must have a printed version of that week's lab exercises with you when you arrive at class. Coming to lab unprepared will be evident to your instructor and will adversely affect your grade (especially if we have a pop quiz that week - see below). Your lab grade makes up slightly more than 1/3 of your grade.

Lab notebook: You are expected to keep a lab notebook throughout the semester; this must be brought to all lab meetings and used for data entry and observation recording throughout the semester. Your laboratory notebook is an essential and required part of this course. I suggest that you construct a lab notebook in a three-ring binder that includes your Biology 105 Lab Manual and into which you insert 8 1/2 " X 11" notebook paper as needed. The key to maintaining a good lab notebook is organization. Please refer to the introduction section for detailed notes on this lab manual. You will receive one final grade for your notebook at the end of the semester; however, the notebook may be collected and graded at any time without warning. Therefore, it is essential to keep your notebook current. See the Introduction section of your lab manual for more information on the lab notebook.

Lab assignments: Throughout the semester, you will be required to turn in lab assignments. These may consist of data analyses, experimental design questions, or problem sets. It is expected (and required) that these represent your own individual work even if they involve analyses of lab experiments completed with a partner/group.

Writing assignments: At least 2 partial (individual) lab reports will be assigned.

Quizzes: On your lab schedule, you will see the dates for 2 quizzes are provided. There will be 2-3 additional quizzes given during the semester, and these will neither be announced, nor will they (necessarily) appear in the same week for individual lab sections. Additional unannounced quizzes may be invoked if students are consistently coming to lab unprepared or late. Quizzes will cover experimental theory, procedures and results from 2 previous labs, general information on the lab to be done that day, and problems and calculations when appropriate.

Participation, preparedness and attendance: Lab attendance is required. If you must miss a lab period due to extenuating circumstances, it is required that you notify your instructor ahead of time. Sometimes, we can arrange for you to attend another section. Attendance means getting to class on time, being there when attendance is taken, and staying for the entire time necessary to complete the lab exercise and clean up afterwards. Good lab performance also includes: participating in discussions, coming to lab prepared, using careful lab technique, doing your part in group experiments, observing safety and laboratory rules, and maintaining a good attitude.

Miscellaneous info: There is a glassware breakage fee - a price list will be posted in the laboratory. Some experiments will require that protective eyeware must be used. Therefore, you must either purchase (or borrow) safety glasses to use during such experiments. There is absolutely no eating or drinking in the laboratory.

Lower Division Science GE Outcomes for Life Forms and the Physical Universe:

1) Students will be able to distinguish a scientific explanation of a phenomenon from a nonscientific explanation.

2) Students will be able to demonstrate their understanding of the basic language and concepts of the science field under study through proper use of the technical/scientific language of that field in the development, interpretation, and application of concepts.

3) Students will be able to critically evaluate conclusions drawn from a particular set of observations or experiments.
Laboratory Schedule

Week	Lab Exercise	Reading^*
1 (1/21)	No labs first week of classes
2 (1/28)	Microscopy, Cell Structure and Function	Sect. A, B,C
3 (2/4)	Lab Quiz on Sect A, B, C, (solutions, dilutions, exponents, pH, etc....) Establish Drosophila melanogaster cultures	Sect. L
4 (2/11)	Osmosis, Diffusion, Water Relationships	Sect. C, D
5 (2/18)	Analysis of Carbohydrate Using the Spectrophotometer	Sect. E
6 (2/25)	Enzymes: Catecholase and Catalase Dilution Problem Set due - 30 pts	Sect. F
7 (3/3)	Fermentation and Respiration	Sect. H
8 (3/10)	Photosynthesis – pigment isolation, etc Lab assignment on enzymes due - 30 pts	Sect. G
9 (3/17)	Spring Break!
10 (3/24)	Photosynthesis – absorption spectra	Sect. G
11 (3/31)	No labs due to Cesar Chavez holiday Monday
12 (4/7)	Mitosis and Meiosis/ Bacterial Transformation	Sect. I, O.
13 (4/14)	Discuss Transformation and D. melanogaster expts. Genetics Problem Set due - 30 pts	Sect. L.
14 (4/21)	Molecular fingerprinting -DNA isolation and PCR D. melanogaster assignment due - 30 pts	Sect. P
15 (4/28)	Molecular fingerprinting – part II- gels and analyses
15 (5/5)	Molecular evolution Final Lab exam – 50 pts Lab Final Quiz. Lab notebooks due. Molecular fingerprint assignment due (30 pts)	Sect. Q

^* Indicates reading from laboratory manual for Biology 105